Your application doesn’t change at all. It still reads process.env.API_KEY or $DATABASE_URL the same way it always did. The difference is where the values come from.
Other instant cameras to consider
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My up-to-date AGENTS.md file for Python is available here, and throughout my time working with Opus, it adheres to every rule despite the file’s length, and in the instances where I accidentally query an agent without having an AGENTS.md, it’s very evident. It would not surprise me if the file is the main differentiator between those getting good and bad results with agents, although success is often mixed.